| Title: | C-reactive protein and cancer risk: a pan-cancer study of prospective cohort and Mendelian randomization analysis |
| Journal: | BMC Medicine |
| Published: | 19 Sep 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36117174/ |
| DOI: | https://doi.org/10.1186/s12916-022-02506-x |
| URL: | https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-022-02506-x |
| Citations: | 47 (47 in last 2 years) as of 8 Aug 2024 |
Publication 10470
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Abstract
BackgroundAlthough observational studies have reported associations between serum C-reactive protein (CRP) concentration and risks of lung, breast, and colorectal cancer, inconsistent or absent evidences were showed for other cancers. We conducted a pan-cancer analysis to comprehensively assess the role of CRP, including linearity and non-linearity associations.MethodsWe analyzed 420,964 cancer-free participants from UK Biobank cohort. Multivariable-adjusted Cox proportional hazards model was conducted to evaluate the observed correlation of CRP with overall cancer and 21 site-specific cancer risks. Furthermore, we performed linear and non-linear Mendelian randomization analyses to explore the potential causal relation between them.ResultsDuring a median follow-up period of 7.1 years (interquartile range: 6.3, 7.7), 34,979 incident cancer cases were observed. Observational analyses showed higher CRP concentration was associated with increased risk of overall cancer (hazard ratio (HR) = 1.02, 95% CI: 1.01, 1.02 per 1mg/L increase, P < 0.001). There was a non-linear association between CRP and overall cancer risk with inflection point at 3mg/L (false-discovery rate adjust (FDR-adjusted) Poverall < 0.001 and FDR-adjusted Pnon-linear < 0.001). For site-specific cancer, we observed positive linear associations for cancers of esophagus and stomach (FDR-adjusted Poverall < 0.050 and FDR-adjusted Pnon-linear > 0.050). In addition, we also observed three different patterns of non-linear associations, including "fast-to-low increase" (head and neck, colorectal, liver, lung, kidney cancer, and non-Hodgkin lymphoma), "increase-to-decrease" (breast cancer), and "decrease-to-platform" (chronic lymphocytic leukemia). Furthermore, the inflection points of non-linear association patterns were consistently at around 3mg/L. By contrast, there was no evidence for linear or non-linear associations between genetically predicted CRP and risks of overall cancer or site-specific cancers.ConclusionsOur results indicated that CRP was a potential biomarker to assess risks of overall cancer and 12 site-specific cancers, while no association were observed for genetically-predicted CRP and cancer risks.</p>
8 Authors
- Meng Zhu
- Zhimin Ma
- Xu Zhang
- Dong Hang
- Rong Yin
- Jifeng Feng
- Lin Xu
- Hongbing Shen
Enabling scientific discoveries that improve human health