| Title: | Seasonal Variations in Vitamin D Levels and the Incident Dementia Among Older Adults Aged ≥60 Years in the UK Biobank1 |
| Journal: | Journal of Alzheimer's Disease Reports |
| Published: | 15 Mar 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38549631/ |
| DOI: | https://doi.org/10.3233/adr-230077 |
| URL: | https://content.iospress.com:443/download/journal-of-alzheimers-disease-reports/adr230077?id=journal-of-alzheimers-disease-reports%2Fadr230077 |
Publication 10110
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Abstract
Background: Limited knowledge exists regarding the association between dementia incidence and vitamin D insufficiency/deficiency across seasons.</p>
Objective: This study aimed to evaluate the impact of seasonal serum vitamin D (25(OH)D) levels on dementia and its subtypes, considering potential modifiers.</p>
Methods: We analyzed 193,003 individuals aged 60-73 at baseline (2006-2010) from the UK Biobank cohort, with follow-up until 2018. 25(OH)D were measured at baseline, and incident dementia cases were identified through hospital records, death certificates, and self-reports.</p>
Results: Out of 1,874 documented all-cause dementia cases, the median follow-up duration was 8.9 years. Linear and nonlinear associations between 25(OH)D and dementia incidence across seasons were observed. In multivariable-adjusted analysis, 25(OH)D deficiency was associated with a 1.5-fold (95% CIs: 1.2-2.0), 2.2-fold (1.5-3.0), 2.0-fold (1.5-2.7), and 1.7-fold (1.3-2.3) increased incidence of all-cause dementia in spring, summer, autumn, and winter, respectively. Adjusting for seasonal variations, 25(OH)D insufficiency and deficiency were associated with a 1.3-fold (1.1-1.4) and 1.8-fold (1.6-2.2) increased dementia incidence, respectively. This association remained significant across subgroups, including baseline age, gender, and education levels. Furthermore, 25(OH)D deficiency was associated with a 1.4-fold (1.1-1.8) and 1.5-fold (1.1-2.0) higher incidence of Alzheimer's disease and vascular dementia, respectively. These associations remained significant across all subgroups.</p>
Conclusions: 25(OH)D deficiency is associated with an increased incidence of dementia and its subtypes throughout the year.</p>
7 Authors
- Jiahao Liu
- Eddy Roccati
- Yutong Chen
- Zhuoting Zhu
- Wei Wang
- Mingguang He
- Xianwen Shang
1 Application
| Application ID | Title |
|---|---|
| 62443 | The eye and the brain |
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