| Title: | Unveiling the link between physical activity levels and dementia risk: Insights from the UK Biobank study |
| Journal: | Psychiatry Research |
| Published: | 28 Mar 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38603980/ |
| DOI: | https://doi.org/10.1016/j.psychres.2024.115875 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090404 |
Publication 10016
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Abstract
BACKGROUND: There is limited information on the mixture effect and weights of light physical activity (LPA), moderate physical activity (MPA), and vigorous physical activity (VPA) on dementia risk.</p>
METHODS: A prospective cohort study was conducted based on the UK Biobank dataset. We included participants aged at least 45 years old without dementia at baseline between 2006-2010. The weighted quantile sum regression was used to explore the mixture effect and weights of three types of physical activity on dementia risk.</p>
RESULTS: This study includes 354,123 participants, with a mean baseline age of 58.0-year-old and 52.4 % of female participants. During a median follow-up time of 12.5 years, 5,136 cases of dementia were observed. The mixture effect of LPA, MPA, and VPA on dementia was statistically significant (β: -0.0924, 95 % Confidence Interval (CI): (-0.1402, -0.0446), P < 0.001), with VPA (weight: 0.7922) contributing most to a lower dementia risk, followed by MPA (0.1939). For Alzheimer's disease, MPA contributed the most (0.8555); for vascular dementia, VPA contributed the most (0.6271).</p>
CONCLUSION: For Alzheimer's disease, MPA was identified as the most influential factor, while VPA stood out as the most impactful for vascular dementia.</p>
6 Authors
- Mingyue Hu
- Kai Zhang
- Kuan-Jui Su
- Tian Qin
- Hui Shen
- Hong-Wen Deng
1 Application
| Application ID | Title |
|---|---|
| 61915 | Multi-omics integrative approaches for discovery and functional studies of putative mechanisms underlying complex human diseases |
Enabling scientific discoveries that improve human health