Impairment of cognitive function (e.g. reasoning, memory and speed) in people with mood disorders has previously received less research and clinical attention than impairment in schizophrenia and neurological conditions. We aimed to quantify the prevalence of cognitive impairment in adults with a history of mood disorder, schizophrenia, multiple sclerosis or Parkinson s disease, within the UK Biobank cohort. After taking into account age and gender differences, direct comparisons in the present study indicated that, relative to participants with no history of psychiatric or neurological conditions, cognitive impairment was least common in major depression and most common in schizophrenia. Impairment prevalence in mania/bipolar disorder was similar to that in multiple sclerosis and Parkinson s disease, both of which are much less common in the population. The high population prevalence of major depression means that the overall burden of cognitive impairment attributable to this disorder is likely to be considerable. A limitation of the study is that information regarding psychiatric and neurological history relied substantially on self-reported diagnoses or responses to questionnaire items. Also, the UK Biobank cohort is not representative of the UK population in some respects, and the groups that we identified within it are likely to differ from psychiatric and neurological samples in other studies and in clinical practice, with regard to sociodemographic characteristics, illness severity and motivational factors.
Cullen B, Smith DJ, Deary IJ, Evans JJ, Pell JP. The 'cognitive footprint' of psychiatric and neurological conditions: cross-sectional study in the UK Biobank cohort. Acta Psychiatr Scand. 2017 Jun;135(6):593-605. doi: 10.1111/acps.12733. Epub 2017 Apr 7.
Cognitive outcomes in people with behavioural and brain disorders within UK Biobank
This research will comprise a series of cross-sectional studies of baseline cognitive data from the UK Biobank resource. Complex statistical models will be used to estimate the relationship between key risk factors (e.g. medical status and genetic markers) and cognitive performance, while taking into account the additional influence of other demographic, social and lifestyle factors.
This research aims to understand the variation of cognitive performance in adults with behavioural and brain disorders such as depression, bipolar disorder and multiple sclerosis. Cognitive impairment is common and functionally disabling in patients with behavioural and brain disorders, but it remains poorly understood at an individual level. This research investigates the nature and extent of cognitive impairment in adults with behavioural and brain disorderes groups compared to healthy controls, and develops multivariate models to explore the relationship between cognitive performance and medical status, demographic and lifestyle factors, and genetic markers. This cross-sectional research aims to contribute to the refinement of hypotheses regarding risk factors for cognitive impairment, providing a foundation for future longitudinal research focused on understanding, preventing and treating cognitive impairment in these groups.
Cullen et al (2017) 'The cognitive footprint of psychiatric and neurological conditions: Cross-sectional study in the UK Biobank cohort', Acta Psychiatrica Scandinavica, 135:593-605. DOI: 10.1111/acps.12733
Cullen et al. Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank. Sci Rep 8, 12089 (2018). https://doi.org/10.1038/s41598-018-30568-6
|Lead investigator:||Breda Cullen|
|Lead institution:||University of Glasgow|