| Application: | 41877, Mechanisms linking season of birth to later-life circadian and mood disorders |
| Title: | Interactions between Season of Birth, Chronological Age and Genetic Polymorphisms in Determining Later-Life Chronotype |
| Size: | 3883 B |
| Archived: | 14 Sep 2021 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 3803
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Notes
Human chronotype, the timing of daily behaviors, is influenced by season of birth and ageing. However, ageing and season of birth influences individuals differently. In this study, we investigated if genetic diversity may explain the heterogeneity in ageing-related change of sleep timing and season of birth effect on later-life chronotype. We found that season of birth may program chronotype in adulthood in a subgroup of people that carry specific genotypes. We also found that genetic variants that are related to epigenetic regulations and DNA repair may be associated with susceptibility towards age-dependent variations of sleep timing. These genetic variants may prove useful as biomarkers for healthy ageing and provide new targets for prediction, diagnosis and treatment sleep problems in older adults.Application 41877
Mechanisms linking season of birth to later-life circadian and mood disorders
Season of birth has been correlated with a number diseases such schizophrenia, diabetes, affective disorders, allergy and neurodegenerative disorders. Chronobiology is also added to this list of phenotypes that is programmed in the early life. Daily preferences (chronotype) of sleeping times may be determined in the postnatal period. Machanism underlying this postnatal programming of biological clock is a focus of interest since a balanced circadian rhythm is essential for physiological and mental health. It has been demonstrated in previous studies that season of birth may modify epigenetics, gene expression, neural activity and brain morphology. A study of UK Biobank data with this magnitude would provide a deeper understanding of the mechanisms underlying the programming effects of early light environment during development. We will compare season of birth and chronotype of participants using staistcal analysis. We aim to investigate how season of birth may alter our daily activity, sleep quality, mood and brain morphology. The environment contributes to our development from in utero to adulthood. In a modern world with light pollution, our rhythm may be disrupted. How illumination of neonatal intensive care units or pregnant mothers working shift work will affect human biology is unknown. The season of birth most likely influences human mood and circadian health. When understood in greater detail, we can provide guidance and policy on best aproaches to maintain good sleep hygiene practices to improve human well-being.
| Lead investigator: | Mr Altug Didikoglu |
| Lead institution: | University of Manchester |
2 related Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3804 | 41877 | Early life factors and COVID-19 infection in England: A prospective analysis of UK Biobank participants. Early Human Development | 14 Sep 2021 |
| 3802 | 41877 | Seasonality and season of birth effect in the UK Biobank cohort | 14 Sep 2021 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 3804 | Interactions between season of birth, chronological age and genetic polymorphisms in determining later-life chronotype | Didikoglu A et al. | 2020 | Mech Ageing Dev |
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