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Using UKBiobank and genetic variants for 25(OH)D (from the Jiang et al 2018 GWAS) to perform Mendelian Randomisation, we have found no evidence that maternal circulating 25(OH)D affects offspring birth weight. We also used genetic variants for serum Calcium (from the O Seaghdha et al 2013 GWAS) to perform Mendelian Randomisation, and we found no evidence of that maternal circulating Calcium affects offspring birth weight in the main analyses, however we did find evidence of masking horizontal pleiotropy.
Understanding how maternal and fetal genetic and environmental factors influence offspring birth weight
We aim to identify genetic and environmental factors that are causally associated with birth weight. Both lower and higher birth weights in the normal range are observationally associated with a higher risk of type 2 diabetes in later life.
Birth weight is influenced by the maternal intrauterine environment, maternal genetics and fetal genetics. Both high and low birth weights have been associated with higher risk of type 2 diabetes in later life, but the causes of these associations are poorly understood. We aim to identify genetic and environmental factors that are causally associated with birth weight.
Mark I McCarthy, Rachel M Freathy, et al. Genome-wide associations for birth weight and correlations with adult disease, doi:10.1038/nature19806