| Application: | 26629, Cross-cultural variations in female reproductive health and non-communicable diseases: analysis of 500,000 participants from the UKBiobank and the InterLACE consortium |
| Title: | Variations in reproductive events across life: a pooled analysis of data from 505,147 women across 10 countries |
| Size: | 938990 B |
| Archived: | 29 Oct 2020 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 2659
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Notes
Mean ages were 12.9 years at menarche, 25.7 years at first birth, and 50.5 years at natural menopause, with significant between-study heterogeneity. A linear trend was observed across birth year for mean age at menarche. The prevalence of nulliparity rose progressively from 14% of women born from 1940 49 to 22% of women born 1970 84; similarly, the mean age at first birth rose from 24.8 to 27.3 years. Women with higher education levels had fewer children, later first birth, and later menopause than women with lower education levels.Application 26629
Cross-cultural variations in female reproductive health and non-communicable diseases: analysis of 500,000 participants from the UKBiobank and the InterLACE consortium
The aim of this study is to incorporate Biobank data as a major addition to the International Collaboration for a Life course Approach to reproductive health Chronic disease Events (InterLACE), a leading international research collaboration. Established in 2012, the focus of InterLACE is on understanding women?s reproductive characteristics and links with the risks of key non-communicable diseases (NCDs), such as cardiovascular disease (CVD), type 2 diabetes, and depression. InterLACE is currently using data from over 230,000 women in 20 studies from nine countries, including Sweden, the USA, Australia, and Japan. Due to the sample size and quality of data collected, the addition of Biobank data with greatly strengthen and expand the research capability of InterLACE. The proposed project is health-related and is in the public interest. Findings will enable the use of reproductive factors as part of an integrated approach to the development of timely and targeted preventive health strategies, such as medical surveillance, to reduce the risk of NCDs. This project will utilise individual-level data from both the UK Biobank and the InterLACE dataset ? see above. Generalised Estimating Equations, multinomial logistic regression, will be used to determine the associations between reproductive factors and and the incidence of NCDs. We would require information only from female participants
| Lead investigator: | Professor Gita Mishra |
| Lead institution: | University of Queensland |
3 related Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 2658 | 26629 | Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data | 29 Oct 2020 |
| 2660 | 26629 | Premenopausal cardiovascular disease and age at natural menopause: a pooled analysis of over 170,000 women | 29 Oct 2020 |
| 2661 | 26629 | Relationships between intensity, duration, cumulative dose, and timing of smoking with age at menopause: A pooled analysis of individual data from 17 observational studies | 29 Oct 2020 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 2660 | Variations in reproductive events across life: a pooled analysis of data from 505 147 women across 10 countries | InterLACE Study Team. | 2019 | Hum Reprod |
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