| Application: | 14864, Evaluation of the causal relation between hematocrit, hemoglobin, HbA1c, testosterone and cardiovascular outcomes in the UK Biobank using Mendelian randomization analysis |
| Title: | Genetic predictors of testosterone and their associations withcardiovascular disease and risk factors: A Mendelianrandomization investigation |
| Size: | 564578 B |
| Archived: | 2 Apr 2020 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 2156
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Notes
Testosterone supplementation has been linked to increased cardiovascular disease risk in some observational studies. We assessed genetic associations of variants in two gene regions that are predictors of testosterone (SHBG and JMJD1C) with several cardiovascular risk factors, coronary artery disease risk and ischaemic stroke risk. There was some evidence of an association for variants in these regions with risk of CAD and with ischaemic stroke in men. This implies that sex hormone-related mechanisms appear to be relevant to cardiovascular risk factors and for stroke (particularly for men). However, the extent that these findings are specifically informative about endogenous testosterone or testosterone supplementation is unclear.Application 14864
Evaluation of the causal relation between hematocrit, hemoglobin, HbA1c, testosterone and cardiovascular outcomes in the UK Biobank using Mendelian randomization analysis
The aims of this study are to examine the causal effect of testosterone, HbA1c, hemoglobin and hematocrit on CVD risk factors, prevalent CVD and CVD deaths using Mendelian randomization analysis, with the relevant genetic variants as instruments in the UK Biobank. The proposed research will help investigate how these potential targets of intervention influence population health using Mendelian randomization design which is less susceptible to confounding than observational studies. The results will provide additional insights concerning the drivers of cardiovascular disease, with corresponding implications for public health policies and the development of interventions. We compare cardiovascular events and risk factors according to levels of genetically determined hematocrit, hemoglobin, HbA1c and testosterone. 500,000 participants (full cohort) for the analysis involving hematocrit, hemoglobin, HbA1c and genetic data. We will restrict the analysis involving testosterone and relevant genetic data among men.
| Lead investigator: | Shiu Lun Ryan Au Yeung |
| Lead institution: | University of Hong Kong |
3 related Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 2151 | 14864 | Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank | 17 Mar 2020 |
| 3619 | 14864 | Impact of Genetically Predicted Red Blood Cell Traits on Venous Thromboembolism: Multivariable Mendelian Randomization Study Using UK Biobank | 2 Jul 2021 |
| 2840 | 14864 | The impact of glycated hemoglobin on risk of hypertension: a Mendelian randomization study using UK Biobank | 20 Nov 2020 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 2157 | Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: A Mendelian randomization investigation | Schooling CM et al. | 2018 | Int J Cardiol |
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