| Application: | 412, Lung function and its association with fatal and non-fatal outcomes |
| Title: | Evaluation of UK Biobank spirograms and derivation of indices from the volume-time curves |
| Size: | 274.1 MB |
| Archived: | 22 Jan 2020 |
| Stability: | Complete |
| Personal: | No individual-level data |
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Notes
The quality of spirometric data is conventionally assessed in terms of acceptability and reproducibility . Volume-time ( curve ) datasets from the Biobank pilot, baseline and repeat examinations were analysed to derive quality control indices for acceptability and a wider range of spirometric measures than are currently available in the main Biobank dataset. These have been assembled into a rectangular dataset to be made available to other Biobank users.Warning messages automatically generated by the Vitalograph spirometer correlated imperfectly with quality control measures derived from the curve datasets. One-third of spirograms that failed internationally recommended acceptability criteria generated no Vitalograph warning message. Since not all the spirograms with blank or accept messages can be assumed to be of good quality, there are advantages in using the directly derived quality indices to evaluate acceptability.
The choice of reproducibility threshold (comparing measures from two blows on the same occasion) was informed by assessing the reliability (between-occasion correlation) of one-second forced expiratory volume (FEV1) and forced vital capacity (FVC), comparing results from the baseline examination to those from the repeat examination performed after an interval of 2-7 years.
Application 412
Lung function and its association with fatal and non-fatal outcomes
The focus of this proposal is to investigate: i. The quality of the spirogram data and provision of recommended algorithms and derived variables that will be of use to other researchers; ii. The cross-sectional determinants of respiratory health and lung function; iii. Its relationship to the future onset of both fatal and non-fatal disease in smokers and never-smokers. This research can be used to understand factors that influence adult lung function, and will guide policies for prevention of both respiratory and non-respiratory mortality. This project requires data on all participants on spirometry, smoking and other lifestyle factors, arterial stiffness, hand grip strength, bone densitometry, anthropometry, cognitive function tests and hearing test. A second phase of this project will require follow-up data on mortality and morbidity records. N/A N/A
| Lead investigator: | Professor David Strachan |
| Lead institution: | St George's, University of London |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 1903 | Lower lung function associates with cessation of menstruation: UK Biobank data | Amaral AF et al. | 2016 | Eur Respir J |
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