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Data from the UK Biobank provides evidence that older adults, aged 60 to 69 years, with near-ideal cardiovascular risk factor profiles have a substantially lower risk of geriatric conditions. Even small reductions in risk factors helped to reduce frailty, as well as dementia, chronic pain, and other disabling conditions of old age. Optimizing cardiovascular disease risk factors may therefore substantially reduce the burden of morbidity in later life.
Genetic and environmental influences on aging well
We aim to identify risk factors and genetic variants associated with ageing well - i.e. having the best health status in the seventh decade of life. We aim to identify factors associated with being free of major ageing diseases (cardiovascular disease, stroke, diabetes, depression or cancer) and consistently in the healthiest range of measures such as muscle strength, cognition, lung function, bone mineral density and blood pressure and key blood tests. Genome wide association studies (GWAS) will identify associated variants for the summary phenotype and for the main components included.
We aim to identify factors associated with being free of major age related diseases and being at the healthier end of measures related to functioning and disease processes in ageing.
Luke C. Pilling, et al. Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers.