| Application: | 735, Risk factors for myopia in adults |
| Title: | Derived variables from application 735/ 15716 - myopia variables |
| Size: | 7.3 MB |
| Archived: | 9 Jun 2015 |
| Stability: | Complete |
| Personal: | Contains individual-level data |
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Notes
Derived variables from application 735/ 15716 - myopia variables. Used in the following publications: Guggenheim JA, Williams C, for the UK Biobank Eye and Vision Consortium. Role of Educational Exposure in the Association Between Myopia and Birth Order. JAMA Ophthalmol. 2015;133(12):1408 1414. doi:10.1001/jamaophthalmol.2015.3556 Guggenheim JA, Williams C, for the UK Biobank Eye and Vision Consortium. Childhood febrile illness and the risk of myopia in UK Biobank participants. Eye 2016; 30: 608 - 614 doi:10.1038/eye.2016.7Application 735
Risk factors for myopia in adults
Short-sightedness (myopia) affects approximately 1 in 3 people in the UK, requiring the use of spectacles, contact lenses, or laser refractive surgery to remove its symptoms of blurred distance vision. As well as this widely recognised inconvenience, short-sighted eyes typically grow larger than normal, which puts them at increased risk of several other sight-threatening disorders. Indeed, a recent Scottish study identified myopia as the 4th most frequent cause of untreatable blindness. By studying the development of short-sightedness in a large sample of UK children (the ?Children of the 90's? cohort) our research team has identified several risk-factors for short-sightedness, including (a) season of birth, (b) birth order, (c) level of physical activity, (d) time spent reading, and (e) time spent outdoors. We are currently assessing the relationship between diet and short-sightedness. In order to test whether our findings in teenagers are replicated in adults, we would like to analyze information collected during the baseline visit of UK BioBank subjects. Specifically, we will compare baseline characteristics in subjects with and without short-sightedness. Ultimately, our work may lead to guidance on lifestyle choices that will minimise the risk of developing this condition.
This category contains data obtained from the analysis of lifestyle choices that minimise the risk of developing myopia that was conducted by the Hong Kong Polytechnic University. Standard epidemiological methods were utilised to determine whether previously identified risk factors associated with myopia in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort of children are replicated in the UK Biobank adult participants (where the correspondence of available data permit such replication). Additional analysis was carried out to test whether febrile illnesses during childhood increase the risk of myopia.
| Lead investigator: | Dr Jeremy Guggenheim |
| Lead institution: | The Hong Kong Polytechnic University |
Enabling scientific discoveries that improve human health