| Title: | Association of the life pattern with the risk of myocardial infarction (MI) in people without standard modifiable cardiovascular risk factors (SMuRFs) |
| Lead Institution: | Chinese Academy of Medical Sciences &Peking Union Medical College |
| Principal investigator: |
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SMuRFs, which include hypertension, dyslipidemia, diabetes mellitus and smoking, are demonstrated to increase the risk of cardiovascular events with no doubts. However, it has been found that a non-negligible proportion of patients with MI combined no SMuRF (13-27%), and the risk of people with no SMuRF is increasing for each year (2004-2019: 11-27%). Therefore, people with no SMuRF, who were described as SMuRF-less status, attached great attentions, and potential reasons for this phenomenon are still not elucidated. Previous studies have demonstrated that unhealthy lifestyles such as unhealthy diet and bad sleep pattern are significantly associated with increased incidence of cardiovascular events. Therefore, it raises great interests that whether the unhealthy life pattern is a pivotal contributor to MI risk in people with SMuRF-less status, which still lacks of explorations. In this investigation, life pattern was evaluated from 7 dimensions: diet, alcohol, sleep pattern, environmental exposure, socioeconomic status and mental health, and the association of different healthy extent of the life pattern with the risk of MI will be investigated in people without SMuRFs. Besides, SMuRF-less people with healthy or unhealthy life pattern will be compared with people with SMuRFs in the risk of MI, further determine the concrete risk brought by unhealthy life patterns in SMuRF-less people. Finally, we will document that whether the unhealthy life pattern is a key point which will bring huge risk of MI and should be paid more attentions in SMuRF-less patients.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9496 | Social isolation, loneliness, and incident type 2 diabetes mellitus: results from two large prospective cohorts in Europe and East Asia and Mendelian randomization | Yanjun Song (+14) | 2023 | EClinicalMedicine |
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