| Title: | The impacts of risk factors such as lifestyle, plasma metabolic markers, and genetic susceptibility on the incidence and mortality of digestive system diseases |
| Lead Institution: | Anhui Medical University |
| Principal investigator: |
Application 912363
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About
Research Questions: This study primarily focuses on three scientific questions: 1) The impact mechanisms of single or combined lifestyle factors on the incidence risk of gastrointestinal diseases; 2) The feasibility of metabolites as biomarkers for early disease diagnosis and prognostic evaluation; 3) The action pathways through which genetic variations and environmental factors interactively regulate disease progression. Research Objectives: We aims to integrate multi-dimensional data to construct a multi-factor risk prediction model, with key objectives as follows: 1). Quantifying the associations between various lifestyle factors and the incidence/mortality of gastrointestinal diseases, and screening independent risk factors; 2). Classifying populations with gastrointestinal diseases based on different risk factors, exploring genetic phenotypes related to specific etiologies, and revealing the genetic-environment interaction patterns of disease occurrence; 3). Developing tools based on machine learning to construct predictive models, and further improving precision treatment strategies for gastrointestinal diseases. Scientific rationale: Gastrointestinal diseases have become a global public health challenge, yet existing studies have several limitations: Lifestyle research is mostly confined to single-factor analysis, lacking systematic exploration of multifactor interactions; Research on genetic-environment interaction mechanisms lags, making it difficult to explain individual risk differences; Most plasma metabolic markers are screened based on small samples, lacking large-sample validation of diagnostic efficacy. We seeks to explore independent and combined effects through collaborative analysis of multi-dimensional factors, enhance the understanding of gastrointestinal disease pathogenesis, and contribute to the development of more effective prevention and treatment strategies.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 21364 | Gout is independently associated with occult hepatic fibro-inflammation independent of obesity: a multi-cohort study using MRI-cT1 and elastography | Yixian Mei (+12) | 2026 | Hepatology International |
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