| Title: | USING GENETICS, PROTEOMICS AND METABOLOMICS IN THE STUDY OF CARDIOMETABOLIC DISEASE |
| Lead Institution: | Uppsala University |
| Principal investigator: |
Application 90143
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About
In this research program we intend to use information of genes, proteins and small molecules (metabolites) to study mechanisms in the body that could lead to cardiovascular disease, such as stroke, myocardial infarction and heart failure, as well as diabetes, high lipid levels and high blood pressure. The discovery of new mechanisms in this respect could potentially lead to new pharmaceutical drugs or new non-pharmacological interventions to lower the burden of cardiovascular disease. A specific focus is on mechanisms whereby obesity could induce cardiovascular disease, since obesity is increasing and is linked to future cardiovascular disease. The analysis of multiple genes, proteins, as well as metabolites, in this research project is very programming and computer-demanding and will take 2-3 years to accomplish.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 13440 | Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank | Lars Lind (+4) | 2024 | Nature Cardiovascular Research |
Enabling scientific discoveries that improve human health