| Title: | Associations of Lifestyle, Environmental factor, Genetic Risk with Aging-related Diseases |
| Lead Institution: | Xiangya Hospital of Central South University |
| Principal investigator: |
Application 90060
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About
Past researchers have demonstrated that genetic factors can increase the risk of aging-related diseases such as multiple cancers, cardiovascular and respiratory diseases and so on. Distinct genes have been identified as genetic factors for specific aging-related diseases through genome-wide scanning. Moreover, the results of studies based on a large population had shown that the risk of aging-related diseases could also be influenced by lifestyle and environment. However, the potential interaction between genetic variants, environment and lifestyle on these aging-related diseases has not been thoroughly investigated. So, we want to conduct this study to examine that if adherence to a healthy lifestyle and improvement of environmental situation can offset genetic risk for aging-related diseases. The estimated duration of this project is 36 months. We expect to find an interaction between genetic risk, environment and lifestyle in aging-related diseases and to remind the public of resisting the genetic risk of aging-related disease by changing specific lifestyles and improving the environment.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 12090 | Ambient air pollution, lifestyle, and genetic predisposition on all-cause and cause-specific mortality: A prospective cohort study | Yiqun Zhu (+12) | 2024 | The Science of The Total Environment |
| 12989 | Association Between Adverse Early Life Factors and Telomere Length in Middle and Late Life | Fengyu Lin (+8) | 2024 | Innovation in Aging |
Enabling scientific discoveries that improve human health