| Title: | To explore the role and underlying mechanisms of circadian rhythm in the development and progression of diabetic retinopathy (DR) |
| Lead Institution: | Shanghai General Hospital |
| Principal investigator: |
Application 88982
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About
Aims: To determine the impact of circadian disruption in the development and progression of diabetic retinopathy (DR). And to investigate the possible mechanisms underlying the association between circadian rhythm and DR. Scientific rationale: DR is the leading cause of preventable vision loss in working population worldwide, and its prevalence remains climbing with growing numbers of diabetes worldwide. Circadian rhythms are a series of behavioral and physiological processes in response to light-dark cycle, and its dysfunction due to sleep/wake disturbance have a strong correlation with eye health and metabolic syndrome through a variety of physiobiological pathways. Therefore, we aim to investigate whether and how circadian rhythmicity interact with the development and progression of DR. Furthermore, the underlying mechanism will be explored through multivariable linear/logistic regression, mediator analysis, and machine learning methods. Project duration: 36 months. Public health impact: This project will benefit millions of people with diabetes with or without DR globally. If risk factors related to circadian rhythms for DR are confirmed, then circadian rhythmicity may provide promising intervention targets and will open new opportunities for the prevention and management of DR.4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9332 | Association of BMI and waist circumference with diabetic microvascular complications: A prospective cohort study from the UK Biobank and Mendelian randomization analysis | Yikeng Huang (+12) | 2023 | Diabetes Research and Clinical Practice |
| 11947 | Diabetes-Related Macrovascular Complications Are Associated With an Increased Risk of Diabetic Microvascular Complications: A Prospective Study of 1518 Patients With Type 1 Diabetes and 20 802 Patients With Type 2 Diabetes in the UK Biobank | Xinyu Zhang (+11) | 2024 | Journal of the American Heart Association |
| 12951 | Loneliness and social isolation are associated with an increased risk of glaucoma: a UK Biobank cohort study | Xinyu Zhu (+9) | 2024 | BMC Public Health |
| 9483 | Walking pace and microvascular complications among individuals with type 2 diabetes: A cohort study from the UK Biobank | Xinyu Zhu (+13) | 2023 | Scandinavian Journal of Medicine and Science in Sports |
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