| Title: | Developing and validating risk prediction and prognostic tools for head and neck cancer. |
| Lead Institution: | University of Glasgow |
| Principal investigator: | Craig Smith |
Application 79789
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About
Our project aims to construct and test the effectiveness / accuracy of a head and neck cancer risk prediction tool - which will support the communication of head and neck cancer risk. At the time of writing, there is a limited number of head and neck cancer risk prediction tools. The incidence of head and neck cancers is rising across the UK. The overall prognosis/ survival rate is usually poor but improves greatly if cases are diagnosed and treated early. It is crucial that any risk prediction tool is validated (i.e tested) on a separate, representative population to assess the predictive accuracy of such a test. This is where the UK Biobank phase of our project comes in. With almost half a million participants recruited from across the UK, this cohort would be the perfect way to assess the effectiveness of our models. This phase would be expected to take roughly at 6 to 9 months, however the overall project will take 36 months. A valid risk prediction tool could serve to help inform the decisions of clinicians and patients of their individual risk. Furthermore, it could serve as a prompt for behavioural change, e.g. referrals to cessation services for smoking. In addition, socioeconomic status is a potential risk factor for head and neck cancer - it is proposed to assess links with socioeconomic factors and head and neck cancer risk in UK Biobank, which could help inform the targeting of interventions / resources. For instance, if a "high risk" prevention strategy was employed risk models could be tailored to those most vulnerable / marginalised.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 11891 | Development and external validation of a head and neck cancer risk prediction model | Craig D. L. Smith (+23) | 2024 | Head & Neck |
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