| Title: | Multi-omic analyses of otorhinolaryngology-related disorders |
| Lead Institution: | West China Hospital of Sichuan University |
| Principal investigator: | Dr Jianjun Ren |
Application 69718
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About
Otorhinolaryngology related diseases, such as head and neck tumors (like nasopharyngeal cancer, laryngeal cancer, hypopharyngeal cancer, oropharyngeal cancer and thyroid cancer), ear diseases (like tinnitus, otitis media, hearing loss and dizziness), nasal diseases (like rhinitis and sinusitis), throat diseases (like polyp of vocal cord, pharyngitis, adenoid hypertrophy and epiglottitis) are very common and annoying diseases, which have brought a huge disease burden to society. Therefore, this project aims to explore the causes and prognosis of these diseases via UK biobank population, so as to reduce the suffering of these diseases in the future and find more suitable prevention and treatment methods. In addition, we also plan to conduct genetic analysis to explore whether gene-related factors could affect the prevalence and prognosis of these diseases or not. During our research process, we will ensure the data security and strictly control research methods in order to obtain the most authentic and reliable research data. In addition, our research group includes not only highly qualified statisticians, but also experienced clinicians, which will make our research topics more rigorous and clinically meaningful. Given the large number of questions we plan to answer with the UK Biobank data, this project will take 36 months. Through the above, obviously our project can bring reformative significance to the promotion of public health. To be more specific, we will construct predictive models (which can intuitively and quickly assess the risk factors, evaluate disease severity, give treatment suggestions and preliminary predict the prognosis, like intelligent scales) that can be tested clinically for their ability to guide screening and treatment decisions to improve patient outcomes. Which means our project can finally be put into practice in clinical works and guide the prevention, diagnosis and treatment of otorhinolaryngology-related disorders. At the end, our final goal of this project is making big significance of decreasing the incidence and mortality of otorhinolaryngology-related disorders.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9322 | A Population-Based Outcome-Wide Association Study of the Comorbidities and Sequelae Following COVID-19 Infection | Yuyang Zhang (+20) | 2023 | Journal of Epidemiology and Global Health |
| 9520 | Associations between immune-mediated diseases (IMDs) and the risk of HPV-associated diseases: a UK Biobank cohort analysis | Lan Feng (+12) | 2023 | BMJ Open |
| 12603 | Associations of sleep and circadian phenotypes with COVID-19 susceptibility and hospitalization: an observational cohort study based on the UK Biobank and a two-sample Mendelian randomization study | Zheran Liu (+10) | 2022 | Sleep |
| 9241 | Low Bone Mineral Density and the Risk of Benign Paroxysmal Positional Vertigo | Junhong Li (+18) | 2023 | Otolaryngology |
| 9278 | Low cholesterol levels are associated with increasing risk of plasma cell neoplasm: A UK biobank cohort study | Linfeng Li (+3) | 2023 | Cancer Medicine |
Enabling scientific discoveries that improve human health