| Title: | Analysis of variants implicated in onset and female-bias in presentation of multiple sclerosis to understand their prevalence and epistatic effect on multiple sclerosis in the general population |
| Lead Institution: | Icahn School of Medicine at Mount Sinai |
| Principal investigator: | Dr Kirill Borziak |
Application 69385
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
The aims of this project is to further characterize alleles that pose a genetic risk for developing multiple sclerosis. A recent family based study has identified a set of alleles that pose a hereditary risk for developing MS. We aim to analyze the prevalence of these alleles in the general population using the UK Biobank dataset to gain better understanding of the importance of these alleles in the onset of MS for unrelated individuals. MS is also aver twice as common in women as it is in men. However, to date very few X-linked alleles have been implicated in the onset of MS and they do not completely explain the increased prevalence of MS in women. This suggests that there are potential other alleles present on the X chromosome which Additionally, we aim to study the interaction between alleles to see using multiple alleles will improve the predictive power of identifying individuals susceptible to MS onset. Previous large scale studies have focused on identifying individual predictive alleles, however, given the variability in the genetic causes of MS susceptibility, we believe a more holistic approach is warranted in identifying the interactions between these alleles.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 7085 | X-linked genetic risk factors that promote autoimmunity and dampen remyelination are associated with multiple sclerosis susceptibility | Kirill Borziak (+1) | 2022 | Multiple Sclerosis and Related Disorders |
Enabling scientific discoveries that improve human health