| Title: | Phenome Wide Association Study of Genetic Loci Associated with Adverse Infection and Immunologic Outcomes |
| Lead Institution: | Duke University |
| Principal investigator: | Dr Svati Shah |
Application 65043
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About
Aims: We aim to use the data available from the UK Biobank to determine all potential disease associations with two genetic variants recently associated with susceptibility to severe COVID-19 infection. Background: The genome is made up of 3 billion base pairs - A, C, T & G - and variation in the genetic code has been identified to be associated with risk for many diseases. Most recently, two genetic loci on chromosome 3 and chromosome 9 were identified to be associated with risk for severe COVID-19 infection. The location on chromosome 9 (ABO) is important in determining blood group and have been previously reported to be associated with risk of both bleeding and clotting complications. The location on chromosome 3 (3p21.31) is more novel and harbors genes related to inflammation, lung disease, hypertension and the entry of SARS-CoV-2 into human cells. It will be valuable to look across many other diseases (phenotypes) to determine other important associations for this genetic variants. Duration: The anticipated project should take approximately 2 years after obtaining access to the data. Public health impact: Despite advances in genetic and other molecular techniques, determination of which patients are at most risk of for a broad array of adverse outcomes, including infectious and immune-system related, is still limited. This project may potentially identify novel associations of diseases associated with the genetic areas we plan to focus. Ultimately we hope this work will lead to more personalized approaches to patient care and improved patient outcomes.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 12527 | Phenome-Wide Association Study of Severe COVID-19 Genetic Risk Variants | Jessica A. Regan (+6) | 2022 | Journal of the American Heart Association |
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