| Title: | Clonal Hematopoiesis of Indeterminate Potential and Atherosclerotic Cardiovascular Disease Phenotypes |
| Lead Institution: | Mayo Clinic |
| Principal investigator: | Dr Iftikhar Kullo |
Application 62427
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About
Clonal hematopoiesis of indeterminate potential (CHIP) is a relatively common, age-related condition that arises with mutations in an individuals' blood cells over time. These mutations can occur in a number of different genes. This condition increases the risk for heart attack, although it is unknown if it also increases the risk of related diseases including stroke, peripheral artery disease, and abdominal aortic aneurysm. We suspect that alterations in how the body handles inflammation due to the CHIP mutations are responsible for the increased risk seen for heart attack and related vascular diseases. Using the genetic data linked with electronic health record data in the UK Biobank and additional databases we plan to: (1) Identify factors associated with CHIP and assess whether CHIP is predictive of adverse cardiovascular events such as heart attack and stroke. (2) Investigate whether CHIP is associated with the four major subtypes of vascular disease (heart attack, peripheral artery disease, stroke, and abdominal aortic aneurysm) and with death and adverse events in these patients. (3) Investigate whether CHIP is associated with markers of inflammation and increased variability in the size of red blood cells. The expected duration of this project is 36 months including quality control stages for the genetic data, preparing data for analyses, conducting association studies, performing meta-analyses for those traits using UK Biobank and Mayo Biorepository datasets, writing, and publishing the manuscript(s) for this project. The results will increase our understanding of the relationship between CHIP and various cardiovascular diseases and explore the driving factors behind this association including inflammation and abnormal red blood cell generation.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9933 | Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1 | Seyedmohammad Saadatagah (+19) | 2024 | JAMA Cardiology |
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