| Title: | Understanding the role of gastrointestinal, hepatic, and cardiovascular factors in neurological disease |
| Lead Institution: | Weill Cornell Medical College |
| Principal investigator: | Dr Neal Parikh |
Application 62323
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About
We will harness the UK Biobank dataset to better understand how common and sometimes subclinical (under-the-surface) manifestations of medical disorders such as intestinal, liver, and heart disorders, impact the occurrence and progression of neurological disorders like dementia and stroke. Our rationale for doing this is that many neurological disorders are incompletely explained; why people get dementia and stroke is not fully known. Based on our prior studies using large datasets from the United States, we hypothesize that subclinical forms of systemic medical disorders independently contribute to the risk of neurological disorders. In terms of public health impact, we hope that better understanding the complex relationships between different organ systems in the body will allow us to identify opportunities to use existing treatments of medical diseases to avert the risk of certain neurological disorders. This may reduce the societal burden of dementia and stroke. We expect that the project will take 2-3 years to complete, especially as our analyses will include detailed MRI imaging analyses.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 7040 | Association of liver fibrosis with cognitive test performance and brain imaging parameters in the UK Biobank study | Neal S. Parikh (+7) | 2022 | Alzheimer's & Dementia |
Enabling scientific discoveries that improve human health