| Title: | Patterns, outcomes and predictors of non-communicable diseases and multimorbidity |
| Lead Institution: | Soochow University |
| Principal investigator: | Dr Chaofu Ke |
Application 60651
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About
Non-communicable diseases, also known as chronic diseases, are the leading cause of death and disability worldwide. With rapid population ageing and increased life expectancy, the coexistence of two or more chronic diseases, termed as multimorbidity, has become a growing public health concern. However, in contrast to a large number of researches focusing on a single chronic disease, studies investigating the mutual relation among non-communicable diseases and the phenomenon of multimorbidity are far from adequate. Therefore, this study aims to make an in-depth investigation into the patterns, outcomes and predictors of non-communicable diseases and multimorbidity. Based on the unique UK Biobank resource, we will establish the causal network of non-communicable diseases and identify specific patterns of multimorbidity. In addition, the impact of major non-communicable diseases and multimorbidity on health impairment and healthcare system will be evaluated. At last, we will identify shared risk factors and pathological mechanisms for common non-communicable diseases, and provide effective prediction models for disease clusters and multimorbidity. We intend to carry out our research with a three-year duration. The findings in this study are expected to provide scientific evidence for the prevention, intervention and care of non-communicable diseases and multimorbidity.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 11725 | Adherence to the EAT-Lancet diet and incident depression and anxiety | Xujia Lu (+7) | 2024 | Nature Communications |
| 10319 | Associations of handgrip strength with morbidity and all-cause mortality of cardiometabolic multimorbidity | Yanqiang Lu (+7) | 2022 | BMC Medicine |
| 10497 | Preserved Ratio Impaired Spirometry and Risks of Macrovascular, Microvascular Complications and Mortality Among Individuals With Type 2 Diabetes | Guochen Li (+9) | 2023 | CHEST Journal |
| 11189 | Preserved Ratio Impaired Spirometry, Metabolomics, and the Risk of Type 2 Diabetes | Guochen Li (+5) | 2023 | The Journal of Clinical Endocrinology & Metabolism |
| 7050 | Role of depression in the development of cardiometabolic multimorbidity: Findings from the UK Biobank study | Yanan Qiao (+5) | 2022 | Journal of Affective Disorders |
Enabling scientific discoveries that improve human health