| Title: | Prevention of myocardial infarction and primary atherogenic cardiovascular disease from a sex-specific life course perspective |
| Lead Institution: | Leiden University Medical Centre |
| Principal investigator: | Dr Raymond Noordam |
Application 56340
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About
Despite several medications have been marketed for the prevention of atherogenic cardiovascular disease, still a considerable proportion of the users experience the disease. First-line prevention of atherogenic cardiovascular disease is difficult due to the increased number of individuals over 65 years of age. With increasing age, many biological processes in the body change or attenuate. In addition, it is unclear to what extend classical risk factors of atherogenic cardiobascular disease show similar increases in risk in individuals of middle and old age. These facts questions whether all pharmaceutical interventions prescribed to individuals still show clear clinical benefit. With medications having clear risks of adverse drug reactions, prescribing a drug at a certain age should have a clear clinical benefit to balance the risk of adverse drug reactions. This project will identify the biological background of atherogenic cardiovascular diseases developed at different ages, using genetic association analyses using the genetic data collected in the UK Biobank. Using the genetics information, we will furthermore determine whether the combination of risk factors (e.g., a high blood pressure and a high LDL cholesterol level) still increase the risk of atherogenic cardiovascular disease in different stages over the life course. The use of these kind of studies usually require immense sample sizes, which are available in the UK Biobank. Using the data collected in UK Biobank, we will determine the biological background and will identify the most suitable targets for interventions to prevent atherogenic cardiovascular disease in younger and older individuals.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 7818 | Cardiovascular risk factors and major recurrent coronary events: A genetic liability study in patients with coronary artery disease in the UK Biobank | Raymond Noordam (+8) | 2023 | Atherosclerosis |
| 10878 | Classical risk factors for primary coronary artery disease from an aging perspective through Mendelian Randomization | Swetta A. Jansen (+7) | 2021 | GeroScience |
| 11511 | Differential and sex- and age-specific risks of cardiometabolic diseases with unrelated metabolic syndrome dimensions | Linjun Ao (+3) | 2023 | Obesity |
| 10833 | Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study | Jiao Luo (+7) | 2022 | Cardiovascular Research |
| 7715 | The impact of sociodemographic status on the association of classical cardiovascular risk factors with coronary artery disease: a stratified Mendelian Randomization study | Leon G Martens (+5) | 2023 | Journal of Clinical Epidemiology |
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