| Title: | Leveraging medical images and deep learning to characterize biological age |
| Lead Institution: | Harvard Medical School |
| Principal investigator: | Professor Chirag Patel |
Application 52887
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About
We aim to predict the age of participants by using deep learning and medical images. This will allow us to identify if people who look older than they actually are are at a higher risk for the onset of different diseases. Estimating the biological age of an individual can help predict the onset of age-related diseases or determine "biological age". It is possible to approximate the biological age by training a model to learn the chronological age of a large cohort of individuals. The predicted age based on the model is known as biological age. The difference between the chronological and biological age is known as age acceleration. In this project, we aim to predict the biological age of organ systems (e.g., heart, pancreas, bone, liver, and brain), from their image data. Specifically, we will first split the image samples for each tissue into a discovery, test, and validation cohort. Second, we will build a deep learning model (convolutional neural network) to predict and validate chronological age of UK Biobank participants based on the image information from these diverse tissues and we will evaluate the prediction accurate based on the test datasets. We will do this iteratively for each tissue. Third, we will estimate the co-variance of biological age between tissues - for example, is heart tissue age correlated with pancreas tissue age. Finally, we will use the new biological age as a phenotype to execute a novel genome-wide association study to determine genetic variants that are associated with our new phenotype of biological age.4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9503 | Association between timing and consistency of physical activity and type 2 diabetes: a cohort study on participants of the UK Biobank | Caiwei Tian (+3) | 2023 | Diabetologia |
| 10993 | Machine learning approaches to predict age from accelerometer records of physical activity at biobank scale | Alan Le Goallec (+5) | 2023 | PLOS Digital Health |
| 11958 | Specification curve analysis to identify heterogeneity in risk factors for dementia: findings from the UK Biobank | Renhao Luo (+5) | 2024 | BMC Medicine |
| 12415 | Using deep learning to predict abdominal age from liver and pancreas magnetic resonance images | Alan Le Goallec (+5) | 2022 | Nature Communications |
Enabling scientific discoveries that improve human health