| Title: | Genome-wide Association Study and Mendelian Randomization Analysis of Early-onset Cancers |
| Lead Institution: | Huazhong University of Science and Technology |
| Principal investigator: | Dr Jiang Chang |
Application 51539
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About
It has been reported that early-onset cancers have distinct molecular genetic mechanisms. Thus, unraveling the pathogenesis of early-onset cancer and identifying biomarkers of it is of great importance. The contribution of genetics and genomics research has identified many risk factors of various diseases, especially cancers. However, the study of germline variants related to the early-onset of cancer is still limited. It has been reported that molecular genetic mechanisms of early-onset cancers are different from elder ones and remain largely unexplained. In addition to genetic susceptibility, environmental factors such as virus infection, diet and smoking are likely to increase the risk of cancer and whether they also contribute to the early-onset cancers are unknown. In this study, we plan to perform genome-wide association studies (GWAS) of all kinds of early-onset cancers and identify germline variants that specifically associated with early-onset cancers. We also plan to perform Mendelian randomization studies to identify potential environmental factors associated with early-onset cancers. The project is scheduled to begin in June 2019 and be completed in December 2021. The research plan is as follows: 1) June 2019 - December 2019: Genome-wide association analysis for early-onset cancers. 2) January 2020 - June 2020: (1) Validation of the early-onset cancer GWAS result using the data of our own. (2) Mendelian randomization studies of potential environmental factors and early-onset cancers. 3) July 2020 - December 2021: summarizing research results, writing research papers.4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9581 | Bidirectional Association Between Cardiovascular Disease and Lung Cancer in a Prospective Cohort Study | Shanshan Zhang (+8) | 2023 | Journal of Thoracic Oncology |
| 11166 | Identification of specific susceptibility loci for the early-onset colorectal cancer | Haoxue Wang (+19) | 2023 | Genome Medicine |
| 7069 | In Utero and Childhood/Adolescence Exposure to Tobacco Smoke, Genetic Risk and Lung Cancer Incidence and Mortality in Adulthood. | Heng He (+19) | 2022 | American Journal of Respiratory and Critical Care Medicine |
| 10251 | In Utero and Childhood/Adolescence Exposure to Tobacco Smoke, Genetic Risk, and Cancer Incidence in Adulthood: A Prospective Cohort Study | Heng He (+15) | 2023 | Mayo Clinic Proceedings |
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