| Title: | Mechanistic modelling of neurodevelopment, neuroplasticity, and neurodegeneration |
| Lead Institution: | McGill University |
| Principal investigator: | Professor Alan Evans |
Application 45551
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About
The goal of this project is to provide a mechanistic modelling of brain structure and function. Our overarching aim is to further our understanding of gene-brain-function relationships. Within this framework of gene-brain-function, we will study brain neurodevelopment and aging trajectories, and their counterpart in neuropsychiatric disorders and neurodegeneration. We will develop disease-specific biomarkers and predict the onset of neurodegenerative disorders and their progression patterns. We will incorporate individual variabilities and predispositions in the process of healthy aging and define healthy aging trajectories. Using this baseline trajectory, we aim to study the causal mechanisms underlying brain alterations in neuropsychiatric disorders, and neurodegeneration. The result of these studies will be made publicly available in form of standard measures, data organization protocols, and statistical analysis tools which will advance our goal of reproducible analysis in neuroimaging and genetics.4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 10921 | Association of Rare Variants in ARSA with Parkinson's Disease | Konstantin Senkevich (+24) | 2023 | Movement Disorders |
| 9410 | Machine learning nominates the inositol pathway and novel genes in Parkinson's disease | Eric Yu (+8) | 2023 | Brain |
| 10177 | Sex differences in cognition and structural covariance-based morphometric connectivity: evidence from 28,000+ UK Biobank participants | Crystal C Yang (+3) | 2023 | Cerebral Cortex |
| 9065 | SparsePro: An efficient fine-mapping method integrating summary statistics and functional annotations | Wenmin Zhang (+2) | 2023 | PLOS Genetics |
Enabling scientific discoveries that improve human health