| Title: | Genetics of complex human traits with a main focus on cardiac disease. |
| Lead Institution: | Copenhagen University Hospital, University of Copenhagen |
| Principal investigator: | Dr Morten Olesen |
Application 43247
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About
Aim: We want to identify genetic causes of complex human traits. Our main focuses are cardiovascular, inflammatory, metabolic and psychiatric diseases. We hope to identify genetic causes of cardiac diseases, and the consequences of concomitant psychiatric, inflammatory and/or metabolic disease. Scientific rationale: Cardiovascular, metabolic and psychiatric disease constitute major health care burdens and despite of many years of extensive research, we are still far from elucidating the exact disease mechanisms. In order to increase our understanding of the pathophysiological mechanisms behind, we will investigate the valuable dataset of UK Biobank and combine the massive data on disease, medication and lifestyle with our prior knowledge of cardiac disease. We hope our research will be beneficial to future research on prevention and treatment. Project duration: We expect that we will work on the analyses of data for the next ten years. We will begin with a project on cardiac heart rhythm disturbances and continue with the other phenotypes that we have mentioned depending on what other research groups publish the next years. Public health impact: We expect to be able to provide valuable insight into the understanding of the biology of the dysfunctional heart, and hopefully contribute to new treatment principles, resulting in the development of personalized medicine.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 10332 | Association of Common and Rare Genetic Variation in the 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene and Cataract Risk | Jonas Ghouse (+4) | 2022 | Journal of the American Heart Association |
| 9487 | Association of DIO2 and MCT10 Polymorphisms With Persistent Symptoms in LT4-Treated Patients in the UK Biobank | Christian Zinck Jensen (+6) | 2023 | The Journal of Clinical Endocrinology & Metabolism |
| 11027 | Association of PCSK9 Loss-of-Function Variants With Risk of Heart Failure | Linea C. Trudsø (+4) | 2023 | JAMA Cardiology |
| 8839 | Loss of Cardiac Splicing Regulator RBM20 Is Associated With Early-Onset Atrial Fibrillation | Oliver B. Vad (+14) | 2023 | JACC Basic to Translational Science |
| 12178 | Potential Influence of Risk Factor Control on the Association Between Lipoprotein(a) and Atherosclerotic Cardiovascular Disease | Jonas Ghouse (+6) | 2024 | Arteriosclerosis Thrombosis and Vascular Biology |
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