| Title: | Evaluating the utility of disease polygenetic risk scores in identifying high-risk individuals using UK Biobank data |
| Lead Institution: | Vanderbilt University Medical Center |
| Principal investigator: | Dr Wei Zheng |
Application 40685
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About
With the rapid surge of genomic information for diseases and traits, there is a growing interest in its application in personalized medicine, including improving individual disease risk prediction. We propose to evaluate whether the aggregate information from multiple common variants associated with respective diseases and traits is useful to identify people who are at high risk of developing certain diseases and traits. By reviewing the literature and analyzing UK Biobank data, we will obtain a list of genetic variants associated with each of the common diseases and traits we would like to investigate, such as cancers and cardiometabolic diseases. We will create a polygenic risk score for each of these diseases and traits using these genetic variants. We will evaluate the association of each of these polygenic scores with their respective diseases and then estimate the proportion of the individuals that could be identified to be at a significantly elevated risk of developing a particular disease or a group of diseases. The results of our proposed study will help to understand the role of aggregate common variants inherited by each individual in determining disease and trait variation in the general population. Our research is in agreement with the aims of UK Biobank: “research intended to improve the prevention, diagnosis and treatment of illness and the promotion of health throughout societyâ€.4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 10867 | Associations of genetic susceptibility to 16 cancers with risk of breast cancer overall and by intrinsic subtypes | Jungyoon Choi (+6) | 2021 | Human Genetics and Genomics Advances |
| 7289 | Effects of Screenings in Reducing Colorectal Cancer Incidence and Mortality Differ by Polygenic Risk Scores | Jungyoon Choi (+5) | 2021 | Clinical and Translational Gastroenterology |
| 12875 | Healthy lifestyles, genetic modifiers, and colorectal cancer risk: a prospective cohort study in the UK Biobank | Jungyoon Choi (+4) | 2021 | American Journal of Clinical Nutrition |
| 8794 | Lifestyle factors, genetic susceptibility to obesity and their interactions on coronary artery disease risk: A cohort study in the UK Biobank | Jungyoon Choi (+6) | 2024 | Preventive Medicine |
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