| Title: | Genome-wide association study of acute respiratory failure in UK Biobank |
| Lead Institution: | University of Pennsylvania |
| Principal investigator: | Dr Blanca Himes |
Application 40375
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About
Acute respiratory failure (ARF) is a common cause of morbidity and mortality in critical illness. Severe ARF is associated with a mortality between 20% to 40%. Few genetics studies have been performed for ARF, and we do not fully understand how genes or the environment influence this disease. We aim to uncover risk determinants of ARF to improve its diagnosis and management. We will use genome-wide association study (GWAS) and gene-environment interaction analysis within the UK Biobank to: 1) identify genetic associations with severe ARF 2) evaluate gene-environment interactions with ARF. Completion of these aims will enhance our understanding of the pathophysiology of ARF.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 7187 | Gene-Based Analysis Reveals Sex-Specific Genetic Risk Factors of COPD. | Jaehyun Joo (+1) | 2022 | AMIA Annual Symposium Proceedings |
| 9121 | Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and Gene-By-Air-Pollution Interaction | Angel C Y Mak (+34) | 2020 | Genetics |
| 12636 | Multiomics analysis identifies BIRC3 as a novel glucocorticoid response-associated gene | Mengyuan Kan (+16) | 2021 | Journal of Allergy and Clinical Immunology |
| 10367 | REALGAR: a web app of integrated respiratory omics data | Mengyuan Kan (+5) | 2022 | Bioinformatics |
| 7293 | Trait Insights Gained by Comparing Genome-Wide Association Study Results using Different Chronic Obstructive Pulmonary Disease Definitions. | Jaehyun Joo (+3) | 2020 | AMIA Joint Summits on Translational Science Proceedings |
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