| Title: | Metabolomics and Genomics of habitual coffee intake and health |
| Lead Institution: | Northwestern University |
| Principal investigator: | Dr Marilyn Cornelis |
Application 21394
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About
Coffee is one of the most widely consumed beverages in the world, and may provide a safe, effective, and readily available preventive/therapeutic agent against multiple diseases and conditions. We are currently studying known and novel metabolite markers of coffee consumption that are amendable to genetic modification. In the current proposal we extend this work by conducting candidate gene-coffee interaction studies on cardiometabolic traits and cognitive function in the UK Biobank cohort. Coffee is one of the most widely consumed beverages in the world and thus represents a significant opportunity to positively affect cardiometabolic health globally. In efforts to identify mechanisms by which coffee impacts health we are proposing health-related research that is in public interest and thus we believe our study meets the UK Biobank?s purpose. We are currently conducting metabolomic and genomic studies of coffee consumption using population-based and clinical based designs. Confirmed metabolite loci will be used to derive genetic scores for coffee exposure and applied in tests of gene -coffee interactions on cardiometabolic traits and cognitive function in the UK Biobank cohort (N~500,000). Full cohort for data analysis5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 12446 | Caffeine Consumption and Dementia: Are Lewy Bodies the Link? | Marilyn C. Cornelis (+4) | 2022 | Annals of Neurology |
| 12478 | Diet and Respiratory Infections: Specific or Generalized Associations? | Thanh-Huyen T. Vu (+4) | 2022 | Nutrients |
| 7433 | Genetic determinants of liking and intake of coffee and other bitter foods and beverages | Marilyn C. Cornelis (+1) | 2021 | Scientific Reports |
| 12256 | Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank : A Prospective Cohort Study. | Maki Inoue-Choi (+5) | 2022 | Annals of Internal Medicine |
| 8582 | Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization | Jue-Sheng Ong (+11) | 2018 | Scientific Reports |
Enabling scientific discoveries that improve human health