| Title: | Understanding the onset and progression of chronic diseases and the role of environment, lifestyle and genetic factors. |
| Lead Institution: | Harbin Medical University |
| Principal investigator: |
Application 203544
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About
The morbidity and mortality rates of chronic diseases are increasing year by year, and have become an important hidden threat to human survival and health. Identifying the key influencing factors of chronic diseases is an important prerequisite for our understanding of the mechanisms of the onset and development of chronic diseases, early identification of high-risk groups, and the formulation of effective public health and medical strategies. However, there are still significant gaps in our understanding of the influencing factors of chronic diseases. There is an urgent need to use large cohorts to explore the causal relationship between environment, lifestyle and genes and chronic diseases. The aim of this study are: (1) to understand the association and strength between the onset and development of multiple diseases and to assess their impact on the risk of death; (2) to construct a genetic risk score, to unite environmental factors and lifestyles, to establish a causal network model for the onset and development of diseases and to systematically elucidate the interactions between environmental factors, lifestyles, and genes; and (3) to establish a risk prediction model for the onset and development of chronic diseases. We intend to carry out our research with a three-year duration. The findings in this study are expected to benefit the identification of vulnerable individuals of non-communicable diseases and improve the precise prevention.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 16840 | Associations of lung function impairment and biological aging with mortality and cardiovascular disease incidence: findings from UK biobank participants | Jiali Chen (+18) | 2025 | Frontiers in Public Health |
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