| Title: | Genetic factors underlying circadian rhythms, sleep, and cardiovascular health |
| Lead Institution: | University of Surrey |
| Principal investigator: | Dr Malcolm von Schantz |
Application 14654
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
We aim to investigate the biological basis for individual differences in circadian rhythms and sleep, and how it relates to cardiovascular markers and health outcomes in different ethnic groups. The published literature suggests a number of links between disturbances in circadian rhythms and sleep and cardiovascular risk factors and negative health outcomes. By further investigating the nature of this link, and the underlying genetic factors, we believe that it will be possible to contribute to the prevention and/or treatment of cardiovascular disease. We will interrogate the UK Biobank's DNA marker database for associations between genetic factors and database entries related to circadian rhythms, sleep, and factors associated with cardiovascular health, and seek single associations as well as shared genetic factors. We will also use the UK Biobank data as a replication cohort for associations found in our own cohort study in Brazil. Full cohort.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 14112 | Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts | Samantha K. Teixeira (+7) | 2024 | Scientific Reports |
| 13900 | Effect of Occurrence of Lamin A/C (LMNA) Genetic Variants in a Cohort of 101 Consecutive Apparent "Lone AF" Patients: Results and Insights | Gabrielle D'Arezzo Pessente (+12) | 2022 | Frontiers in Cardiovascular Medicine |
Enabling scientific discoveries that improve human health