| Title: | Effects of environmental and nutritional exposures on the risk of cardiovascular and cerebrovascular diseases and its potential mechanisms |
| Lead Institution: | University of Electronic Science and Technology of China |
| Principal investigator: |
Application 129048
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About
Aims: In this project, we sought to examine the longitudinal effects of environmental and nutritional exposures on the risk of cardiovascular and cerebrovascular diseases within a large prospective cohort. We will investigate how environmental and nutritional exposures mediate the development of cardiovascular and cerebrovascular diseases via biomarkers by utilizing mediation effect analysis. In addition, we further aim to examine whether genetic predisposition could modify the association of environmental and nutritional exposures with cardiovascular and cerebrovascular diseases risk. Scientific Rationale: Cardiovascular and cerebrovascular diseases remain the leading cause of death worldwide. With the deepening of industrialization and the changes in lifestyle, the role of environmental and dietary factors in the occurrence and development of chronic non-communicable diseases, mainly represented by cardiovascular and cerebrovascular diseases, is increasingly being valued. Previous epidemiological studies have generally focused on the effect of short-term air pollution or a single food intake on cardiovascular disease, accompanied by limitations on sample size and follow-up time, which frequently ends in contradictory findings. In addition, environmental and nutritional factors usually affect diseases through certain intermediate processes, but there hasn't been much population study to investigate potential mechanisms. Furthermore, A substantial body of evidence has confirmed that phenotypic expression of cardiovascular disease is a result of interacting genetic and environmental factors, and that genetic predisposition may alter the relationship between environmental exposure and disease outcome. To design focused preventative and management measures, it is essential to comprehend the possible modification by genetic predisposition. Project Duration: The project is expected to last 3 years from the date of data access. Public Health Impact: This project will contribute to a better understanding of how environmental and nutritional factors affect cardiovascular and cerebrovascular diseases, provide an important foundation for environmental pollution control and food processing policies, and provide guidance for the proposal of personalized prevention strategies.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 13133 | Association of triglyceride-glucose index and its combination with adiposity-related indices with the incidence of myocardial infarction: a cohort study from the UK Biobank | Jie Zhou (+9) | 2024 | International Journal of Obesity |
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