| Title: | Comprehensive investigation of biomarkers and medical conditions in relation to subsequent hematological disorders or cancer |
| Lead Institution: | Nanfang Hospital, Southern Medical University |
| Principal investigator: |
Application 106912
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About
The nature of disease is a continuous process but not a categorical definition. Investigating biomarker changes or medical conditions (or disease) in early stage before clinical onset of subsequent disease is of much importance, which could provide evidence for early intervention or screening and provide clue for understanding potential biological mechanism. In this project, we will mainly focus on diseases that are strongly related to serum biomarker changes including hematological disorders and cancer. To be more specific, we aim to: 1) systematically investigate influence factors (risk factors or protective factors) of the association between biomarkers or medical conditions (or disease) in earlier stage and subsequent hematological disorders and cancer in later stage, which could help to provide knowledge for disease prevention and screening; 2) identify novel biomarkers or early medical conditions that are related to subsequent hematological disorders and cancer, and explore the associations of biomarkers or medical conditions (or disease) that are related to hematological disorders and cancer with other disorders (beyond hematological disorders and cancer); 3) investigate impact of these biomarkers or medical conditions (or disease) in earlier stage on the prognosis of subsequent hematological disorders or cancer. Taken together, our findings could provide evidence for early intervention or screening and would be helpful for understanding biological basis for the associations of interest.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 12765 | Clonal hematopoiesis of indeterminate potential and risk of neurodegenerative diseases | Xinyuan Liu (+6) | 2024 | Journal of Internal Medicine |
| 12727 | Clonal hematopoiesis of indeterminate potential and the risk of pulmonary embolism: an observational study | Qianwei Liu (+6) | 2024 | EClinicalMedicine |
Enabling scientific discoveries that improve human health